This study is currently not recruiting participants.

Effect of low intensity vibration (LIV) on aromatase inhibitor- induced musculoskeletal dysfunction in early stage breast cancer survivors

Investigation of Low Intensity Vibration on Muscle and Bone Health in Breast Cancer Patients

Not Recruiting
18 years - 100 years
Female
Phase N/A

Brief description of study.

A type of breast cancer medicine called aromatase inhibitors (AI) causes muscle weakness and bone loss in patients. This research is being done to test whether low intensity vibration (LIV) can prevent the loss of muscle and bone strength in patients receiving AIs.

Detailed description of study

The primary objective of this study is to compare the effect of LIV delivered for 10 minutes twice daily for 12 months on skeletal muscle function, in terms of energetic capacity measured by power generation on a stationary bicycle, among patients with early stage breast cancer planned to initiate aromatase inhibitor therapy who do not currently participate in regular exercise, compared to a wait- listed control.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: breast cancer
  • Age: 18 years - 100 years
  • Gender: Female

This study investigates whether low intensity vibration (LIV) can prevent muscle weakness and bone loss in patients with early stage breast cancer who are starting treatment with aromatase inhibitors (AIs). AIs are medications used in breast cancer treatment that can lead to muscle and bone deterioration.

Participants will use LIV, which involves gentle vibrations, for 10 minutes twice daily over a period of 12 months. The study will measure how this affects their muscle function, specifically their ability to generate power on a stationary bicycle. The results will be compared to a group of patients who do not receive LIV.

  • Who can participate: Participants must have early stage breast cancer and be planning to start aromatase inhibitor therapy. They should not be currently engaging in regular exercise.
  • Study details: Participants will use a device that delivers low intensity vibration for 10 minutes twice daily. The effects on muscle function will be measured using a stationary bicycle.
  • Study Timelines: The study will last 12 months.
Updated on 19 Feb 2024. Study ID: 1808152332

Interested in the study?

Select a study center that’s convenient for you, and get in touch with the study team.

Connect with the study team