This protocol will consist of the collection of either

1)      A single ~43 mL sample of venous blood, along with a limited set of phenotypic and clinical laboratory data (if available). 
2)      A set of timed blood samples collected before and after a 75g oral glucose load, totaling ~270 mL, along with the same limited set of phenotypic and clinical laboratory data (if available)

This project is a component of the Translation Core of the NIH P-30 funded Indiana University Diabetes Research Center. We will be collecting samples from individuals with obesity and/or diabetes and from normal healthy controls (for comparison purposes). The sample will be either frozen (in sub-aliquots) or transferred fresh to a client laboratory in specific circumstances where this is needed. Frozen samples will be stored for up to 10 years, then discarded if not used. Samples will be transferred to a client laboratory within the IU or Indiana CTSI family. Use of these samples by client laboratories will take place under separate IRB-approved protocols. Along with the sample(s), a de-identified dataset including the phenotypic data described below will be provided. Sample transfers to client laboratories will be tracked, and the number of samples shared each year will be reported.