Hypercapnia and voluntary activation of the diaphragm
Study on Effects of High Carbon Dioxide Levels on Breathing Muscles
Brief description of study.
The purpose of this study is to determine whether or not high-level circulatory CO2 brings about fatigue of the breathing muscle via assessing the changes in voluntary activation of the diaphragm.
Detailed description of study
The purpose of this study is to investigate the influence of high-level arterial carbon dioxide, hypercapnia, on the central neural drive to the breathing muscle.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Hypercapnia
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Age: 18 years - 40 years
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Gender: All
The purpose of this study is to investigate the influence of high-level arterial carbon dioxide, also known as hypercapnia, on the central neural drive to the breathing muscle. This study looks at how increased levels of carbon dioxide in the blood might affect the diaphragm, which is the main muscle used for breathing.
Participants will undergo procedures to assess the changes in voluntary activation of the diaphragm. This means researchers will measure how well the diaphragm responds when instructed to contract, helping to understand if high CO2 levels cause fatigue in the breathing muscle.
- Who can participate: Participants must meet age criteria and other key eligibility factors, which include being healthy adults between 18 and 50 years old with no history of respiratory disorders.
- Study details: Participants will undergo tests to measure the diaphragm's response to voluntary activation. This involves assessing how the diaphragm contracts under different levels of carbon dioxide in the blood.
Interested in the study?
Select a study center that’s convenient for you, and get in touch with the study team.
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