This study investigates the effects of subtotal microsurgery combined with stereotactic radiation therapy on large acoustic neuromas. Acoustic neuromas are non-cancerous tumors that develop on the nerve responsible for balance and hearing, which can affect facial nerve function. The aim is to see if this combination can improve facial nerve function without affecting the control of the tumor.

Participants in this study will undergo subtotal microsurgery followed by stereotactic radiation therapy. Subtotal microsurgery involves removing part of the tumor, while stereotactic radiation therapy uses focused radiation beams to target the tumor. This approach aims to balance effective tumor management with the preservation of facial nerve function.

• Who can participate: Adults aged 18 and older with a diagnosis of large acoustic neuromas who have not responded to other treatments may be eligible to participate. Additional eligibility criteria include overall health status and specific medical history requirements.
• Study details: Participants will first undergo subtotal microsurgery, where a portion of the tumor is removed. This is followed by stereotactic radiation therapy, which uses precise radiation beams to target the remaining tumor. The study will monitor the effects on facial nerve function and tumor control. A placebo is not used in this study.