Phase Ib and Phase II Studies of anti-PD-1 Antibody Pembrolizumab (MK-3475) in Combination with Bevacizumab for the Treatment of Metastatic Renal Cell Carcinoma: Big Ten Cancer Research Consortium BTCRC-GU14-003
Investigating the Safety and Activity of an Investigational Medication Combination for Metastatic Kidney Cancer
Brief description of study.
The purpose of this study is to find the maximum safe dose of pembrolizumab (also known as MK-3475) in combination with bevacizumab that can be given to patients with metastatic clear cell kidney cancer.
Detailed description of study
The purpose of this study is to determine the activity of the combination of pembrolizumab and bevacizumab in first line therapy for subjects with metastatic clear cell RCC as assessed by response rate.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Renal Cell Carcinoma
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Age: 18 years - 100 years
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Gender: All
The purpose of this study is to investigate the maximum safe dose of an investigational medication in combination with another investigational treatment for patients with metastatic clear cell kidney cancer. Metastatic clear cell kidney cancer is a type of kidney cancer that has spread to other parts of the body.
Participants will receive a combination of the investigational treatments. The study will assess the response rate to this combination in patients who have not received prior therapy for their metastatic clear cell kidney cancer.
- Who can participate: Participants must be adults diagnosed with metastatic clear cell kidney cancer who have not received previous treatment for their condition. Other eligibility criteria include adequate organ function and no history of severe cardiovascular diseases.
- Study details: Participants will receive a combination of investigational treatments to assess their response. The study aims to find the maximum safe dose and activity of this combination.
Interested in the study?
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