This study is currently not recruiting participants.

Hypothermia's Impact on Pharmacology

Study on How Heart Problems Affect Medicine Processing in Kids

Not Recruiting
100 years or below
All
Phase N/A

Brief description of study.

The purpose of this study is to identify the physiologic manifestations of cardiac arrest and multi organ dysfunction syndrome (MODS) that underlie the variability in morphine and midazolam pharmacokinetics; to estimate the impact of genetic factors on the variability in morphine and midazolam pharmacokinetics, specifically in the setting of pediatric cardiac arrest; and to estimate the impact of hypothermia on the variability in morphine and midazolam pharmacokinetics in children after cardiac arrest.

Detailed description of study

The purpose of this study is to identify the physiologic manifestations of cardiac arrest and multi organ dysfunction syndrome (MODS) that underlie the variability in morphine and midazolam pharmacokinetics; to estimate the impact of genetic factors on the variability in morphine and midazolam pharmacokinetics, specifically in the setting of pediatric cardiac arrest; and to estimate the impact of hypothermia on the variability in morphine and midazolam pharmacokinetics in children after cardiac arrest.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: cardiac arrest
  • Age: 100 years or below
  • Gender: All

This study investigates how cardiac arrest and multi-organ dysfunction syndrome (MODS) affect the way children's bodies process certain medications. Specifically, it looks at morphine and midazolam, which are drugs used to manage pain and anxiety. The study also considers how genetic factors might influence this process, particularly in children who have experienced cardiac arrest.

Participants in the study will undergo procedures to observe how their bodies handle these medications. The study will also explore the role of hypothermia, a treatment that lowers body temperature, on the processing of these drugs after cardiac arrest. This information will help understand the variability in drug effects among children with these conditions.

  • Who can participate: Children who have had a cardiac arrest and are being treated may join. The study includes those with MODS and considers genetic factors.
  • Study details: Participants will receive morphine and midazolam to observe how their bodies process these medications. The study will also assess the effects of hypothermia treatment. A placebo, which is an inactive substance, will not be used in this study.
Updated on 19 Feb 2024. Study ID: 1212010220

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