Comparing Low-Dose vs. High-Dose Aspirin for Fever Recrudescence in Kawasaki Disease

Aspirin (ASA), along with high-dose intravenous immunoglobulin (IVIg), is recommended for the initial treatment of patients with Kawasaki disease (KD). There is a wide range of practice variation in regards to aspirin dosing (high vs. low) among institutions. The optimal ASA dose for patients with KD is unknown. Studies have shown low-dose ASA in acute KD is not inferior to high-dose ASA for reducing the risk of coronary artery abnormalities, but there is limited data on ASA dose and the rate of recurrent fever in children with acute KD. We aim to evaluate this by conducting a retrospective review of children admitted to Riley Hospital for Children with KD between 2009-2017, during which time we transitioned from low-dose to high-dose ASA for the initial treatment of children with KD.

You may be eligible for this study if you meet the following criteria:

• Conditions: Kawasaki Disease
• Age: 100 years or below
• Gender: All