This study investigates whether subcutaneous injections of a combination of certain medications can reduce blood loss and the need for transfusions in infants. The condition being studied is sagittal synostectomy, a surgery performed to correct a specific type of skull abnormality in infants. In this context, the study is exploring if using these injections can make the surgery safer by minimizing blood loss.

Participants in the study will receive injections under the skin that include a mix of medications. These medications are being tested to see if they work together to reduce the amount of blood lost during surgery. The study will involve monitoring the infants to see if the injections are effective in reducing the need for blood transfusions.

• Who can participate: Infants eligible for participation are those diagnosed with craniosynostosis requiring sagittal synostectomy. Participants must be within the age range of 3 to 12 months and meet specific health criteria as determined by the study protocol.
• Study details: Participants will receive subcutaneous injections that include a combination of medications. The study will observe if these injections help reduce blood loss during the surgery. A placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine, might be used for comparison.