Effects of Precuneus Repetitive Transcranial Magnetic Stimulation (rTMS) on Self-Referential Processing and Default Mode Network Functional Connectivity in Early Phase Psychosis

Study on Repetitive Transcranial Magnetic Stimulation (rTMS) for Schizophrenia

Recruiting
18 years - 45 years
All
1 Location

Brief description of study.

The purpose of this study is to determine if the study treatment, repetitive transcranial magnetic
stimulation (rTMS), helps improve symptoms of your illness and adjusts communication between
related areas of the brain. rTMS is a non-invasive technique that applies a magnetic field over the scalp
to cause activation within the brain.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Schizophrenia,schizoaffective disorder
  • Age: 18 years - 45 years
  • Gender: All

Inclusion Criteria

1.    Between 18 and 45 years of age
2.    Within 10 years of illness onset as defined by entry into treatment for psychotic symptoms
3.    Able to give informed consent
4.    Willing and able to adhere to the study schedule
5.    Structured Clinical Interview for DSM-5 (SCID-5)67 diagnosis of schizophrenia or schizoaffective disorder
6.    Clinical stability as defined by your care provider.

Exclusion Criteria

1.    Lifetime history of a seizure, excluding febrile seizures and those induced by substance withdrawal
2.    First degree relative (that is, biological father, mother, brother, sister, or child) with idiopathic epilepsy or other seizure disorder
3.    History of significant neurological illness (including stroke, CNS infection with persistent neurologic deficit, or other event deemed significant by PI)
4.    History of head trauma as defined by a loss of consciousness or a post-concussive syndrome
5.    Pregnant or breast feeding
6.    Known IQ < 70 based
7.    Current acute, serious, or unstable medical conditions, including, but not limited to: inadequately controlled diabetes, asthma, COPD, severe hypertriglyceridemia, recent cerebrovascular accidents, acute systemic infection or immunologic disease, unstable cardiovascular disorders, malnutrition, or hepatic, renal gastroenterological, respiratory, endocrine, neurologic, hematologic, or infectious diseases based on medical history or physical examination
8.    Metallic objects planted in or near the head, including implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit, ventriculoperitoneal shunt, or cochlear implants
9.    Contraindications to MRI or otherwise unable to tolerate MRI procedures
10.    History of electroconvulsive therapy
11.    Taking clozapine
12.    Participated in a clinical trial with any pharmacological treatment intervention for which they received study-related medication in the 4 weeks prior to randomization
13.    Considered a high risk for suicidal acts – active suicidal ideation as determined by clinical interview OR any suicide attempt in 90 days prior to screening
14.    Current DSM-5 diagnosis of substance use disorder (excluding nicotine or caffeine)
15.    Require concomitant treatment with prohibited medication

Updated on 19 Feb 2024. Study ID: 1904511224

This study investigates the use of repetitive transcranial magnetic stimulation (rTMS) for individuals with schizophrenia or schizoaffective disorder. Schizophrenia is a mental health condition that affects how a person thinks, feels, and behaves. The purpose of this study is to see if rTMS can improve symptoms and communication between brain areas. rTMS is a non-invasive method that uses magnetic fields to stimulate nerve cells in the brain.

Participants will undergo rTMS treatment sessions. The study will monitor changes in symptoms and brain activity. rTMS involves placing a magnetic coil on the scalp to deliver magnetic pulses. This technique is painless and does not require surgery.

  • Who can participate: Adults aged 18 to 45 years with a diagnosis of schizophrenia or schizoaffective disorder may participate. Participants should be within 10 years of illness onset and able to provide informed consent. They must also be clinically stable and willing to follow the study schedule.
  • Study details: Participants will receive repetitive transcranial magnetic stimulation (rTMS) sessions. This involves placing a magnetic coil on the scalp to deliver magnetic pulses.

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