Insights into the Lid Margin: Characterization of Membrane Associated Mucins in Ocular Surface Disease
Investigating Proteins in Dry Eye Disease
Brief description of study.
Dry eye disease affects millions of people worldwide and due to an incomplete understanding of the pathogenesis of the disease, it is widely underdiagnosed and undermanaged by clinicians. Understanding the contribution of the proteins involved in maintaining boundary lubrication between the ocular surface and eyelids, specifically mucins, may lead to better understanding of disease and potentially to earlier diagnosis of dry eye. The aim of this project is to investigate mucins on the ocular surface and examine differences in people with and without dry eye disease.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Dry Eyes
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Age: 18 years - 100 years
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Gender: All
Inclusion Criteria:
All subjects must be:
oAble to understand and sign an informed consent and HIPAA privacy document.
o18 years of age or older.
oAble and willing to follow protocol instructions.
Subjects will be telephone screened to determine if the subject falls into either Group 1: Dry Eye or Group 2: Normal, depending on the type of subjects still needed to meet enrollment goals.
Group 1 Dry Eye Disease Inclusion:
OSDI score > 33 (administered via telephone screener)
Group 2 Normal Inclusion:
OSDI score < 10 (administered via telephone screener)
All subjects that meet the inclusion/exclusion criteria and consent to participating in the study will be enrolled.
Data obtained will then be segregated based on clinical findings for later analysis.
Exclusion Criteria:
1. Under the age of 18
2.Current contact lens wearer (any wear of contact lenses in the past 3 months)
3.Use of any of the following ophthalmic medication within 30 days: antibiotics, anti-fungal, anti-allergy, anti-inflammatory, anti-glaucoma, lifitegrast, restasis
4.Use of artificial tears within 2 days of study visit
5.Active ocular infection or acute allergic conjunctivitis
6.Transmissible or contagious disease such as HIV, TB, measles, meningitis, etc.
7.Significant conjunctival scarring, obvious meibomian gland dysfunction, or other serious ocular condition
8.History of ocular surgery in the past 12 months
9.Participation in a clinical trial involving a drug or device in the past 30 days
10.Pregnant or nursing by self-report
This study investigates dry eye disease, a condition affecting many people worldwide. The purpose is to understand the role of mucins, which are proteins that help with lubrication between the eye surface and eyelids. By comparing people with and without dry eye disease, researchers hope to learn more about the condition and improve diagnosis.
Participants in this study will undergo screening to determine their group based on their OSDI score, a measure of dry eye symptoms. The study will involve collecting data about mucins on the ocular surface, which will then be analyzed to identify any differences between the groups.
- Who can participate: Adults aged 18 or older who can understand and sign consent forms may participate. They must not wear contact lenses or use certain eye medications recently.
- Study details: Data collected will be analyzed to understand differences in mucins between those with and without dry eye disease.
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