Role of Aging in GCN2-dependent wound healing
Investigating the Body's Stress Response in Wound Healing and Aging
Brief description of study.
When a normal healthy adult’s skin is wounded, their skin usually heals without difficulty; however, if a person damages their skin while they are sick or if they have a chronic disease, the wound may not heal as quickly. Also, as we age, the wound healing process is slowed and delayed. The purpose of this study is to examine acute wound healing to determine whether a specific mechanism in how we respond to stress plays a role in the aging-related decline in wound healing. It will determine whether defects in this stress response occur with age and if it suppresses wound healing.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy
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Age: 20 years - 100 years
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Gender: All
Inclusion Criteria
1.Age: either between 20-28 years old or at least 65 years old
2.Good general health
Exclusion Criteria
1.Diagnosis of diabetes mellitus
2.History of abnormal scarring
3.History of immunosuppression
4.History of abnormal skin infections
5.Allergies to xylocaine anesthetic
6.History of bleeding disorders
7.Use of anticoagulants
8.Unable to understand informed consent document
This study investigates how the body's response to stress affects wound healing, especially as people age. Wound healing is the process where the skin repairs itself after injury. In younger, healthy individuals, this process usually happens smoothly. However, the study aims to understand why healing slows down in older adults and if a specific stress response mechanism is involved.
Participants will undergo procedures to create small wounds under controlled conditions to observe the healing process. The study will look for any defects in the stress response that might affect healing as people get older. Complex medical terms like 'acute wound healing' refer to the body's immediate response to skin injury.
- Who can participate: Participants must be either between 20-28 years old or at least 65 years old and in good general health. Individuals with diabetes, abnormal scarring, immunosuppression, skin infections, allergies to xylocaine, bleeding disorders, or those taking anticoagulants are excluded.
- Study details: Participants will have small wounds created under controlled conditions to study how their skin heals. The study will examine the stress response related to aging. A placebo is not used in this study.
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