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Methods to Identify and Treat Severe Asthma Patients Project 2: Airway pH Phenotyping
Investigating Airway pH in Asthma and Cystic Fibrosis
Recruiting
18 years - 50 years
All
Phase
N/A
1 Location
Brief description of study.
Airway pH in airway health and disease
Not all
people with asthma respond well to traditional treatments. This could be
because of acid levels in a person’s airway. Acid in the airway inhibits the
body’s response to infection and increases inflammation. If medical
professionals can easily measure patients’ pH, they could better identify an
appropriate, even personalized, treatment.
It has been shown that acid
in the airway affects the body’s response to infection, increases inflammation
and affects how well some common medications work. Right now, airway pH can be measured most
accurately by a bronchoscopy, a procedure where a camera is inserted into the
airway. Our goal is to develop an
easier, non-invasive way of measuring pH that can be done in a doctor’s office. This will allow us to use targeted,
personalized medicine to treat patients!
Detailed description of study
This is a three to four visit study, spanning approximately two-six weeks, in which subjects with asthma, cystic fibrosis, and healthy adult volunteers will undergo screening, baseline characterization, a non-invasive challenge test with inhaled alkaline glycine buffer, followed by repeated measurements of airway function and inflammation, and a research bronchoscopy.
For
more information, call us at 317-274-3380 or email IUasthma@iupui.edu
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: asthma,cystic fibrosis
-
Age: 18 years - 50 years
-
Gender: All
Project 2-Airway pH Phenotyping is for people with asthma or cystic fibrosis who also:
- Are
18 – 50 years old
- Have had no recent flares
- Have had no recent change in
medication
- Are
available for 3-4 clinic visits over 4-6 weeks
Updated on
19 Feb 2024.
Study ID: 1904631922
This study investigates how the pH level in the airway may affect people with asthma and cystic fibrosis. It looks at how acid in the airway can change the body's response to infections and increase inflammation, which might make usual treatments less effective. The study aims to find a simpler way to measure airway pH, which is currently done using a bronchoscopy, a procedure involving inserting a camera into the airway.
Participants will undergo a screening process and baseline characterization. They will take part in a non-invasive challenge test using an inhaled alkaline glycine buffer. Afterward, repeated measurements of airway function and inflammation will be taken, along with a research bronchoscopy.
- Who can participate: Adults aged 18 to 50 with asthma or cystic fibrosis can participate if they have had no recent flares or changes in medication. Participants must be available for 3-4 clinic visits over 4-6 weeks.
- Study details: Participants will attend clinic visits and are responsible for undergoing tests such as a non-invasive challenge test and a bronchoscopy.
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