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GSNOR Phenotyping/GSNO Challenge in Severe Asthma
Asthma and Airway Function Study Using an Investigational Method
Recruiting
18 years - 50 years
All
Phase
N/A
1 Location
Brief description of study.
This is a three to four visit study, spanning approximately two to six weeks, in which subjects with asthma and healthy volunteers will undergo screening, baseline characterization, a research bronchoscopy, and a non-invasive challenge test with inhaled GSNO followed by repeated measurements of airway function and inflammation.
Detailed description of study
Asthma is common but some people don’t respond to traditional treatments. This could be
because some asthma patients have high levels of a protein (GSNOR) that reduces the amount
of a chemical that relaxes airway muscles (GSNO) in their body. This can lead to the airway
muscles tightening which can cause symptoms like coughing, wheezing and shortness of
breath. There may be drugs that can target this process but first we must identify which patients
have high levels of this protein. We are developing a practical method to do just that.
For more information, call us at 317-274-3380 or email IUasthma@iupui.edu
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: asthma
-
Age: 18 years - 50 years
-
Gender: All
The GSNO Study is for people with asthma who also:
- Are 18 – 50 years old
- Have had no recent flares
- Have had no recent change in medication
- Are available for 3-4 clinic visits over 2-6 weeks
Updated on
19 Feb 2024.
Study ID: 1904630156
This study investigates asthma, a common condition where some patients do not respond well to traditional treatments. This may be due to high levels of a protein called GSNOR that reduces GSNO, a chemical that helps relax airway muscles. When GSNO levels are low, airway muscles can tighten, leading to symptoms such as coughing, wheezing, and shortness of breath. The purpose of this study is to identify patients with high levels of GSNOR to develop a practical method for targeting this process.
Participants will undergo several procedures including screening, baseline characterization, a research bronchoscopy, and a non-invasive challenge test with inhaled GSNO. This will be followed by repeated measurements of airway function and inflammation. A bronchoscopy is a procedure where a doctor looks at the airways through a thin viewing instrument called a bronchoscope.
- Who can participate: This study is for individuals aged 18 to 50 years who have asthma. Participants should not have had recent asthma flare-ups or changes in medication. They should be available for 3-4 clinic visits over 2-6 weeks.
- Study details: Participants will take part in screening and baseline tests, followed by a bronchoscopy and a challenge test with inhaled GSNO. A bronchoscopy involves using a thin tube to look inside the airways.
- Study Timelines and Visits: The study will last 2-6 weeks. The study requires 3-4 visits.
Pre-Screener
