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Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy (HASTE)
Investigating Anesthesia Techniques in Stroke Patients
Recruiting
100 years or below
Male
4 Locations
Brief description of study.
Brief Summary:
The goal of this randomized controlled trial is to compare manual general anesthesia induction to general anesthesia induction guided by target controlled infusion system in cerebral ischemic stroke
The main questions it aims to answer are:
- Does target controlled infusion has a more favorauble hemodynamic profile than manual general anesthesia induction?
- Do patients receiving general anesthesia with target controlled infusion system have a more favourable outcome? Participants will receive general anesthesia induction with a target controlled infusion system and will be compared to patients receiving manual general anesthesia induction.
Detailed description of study
Study Type :Interventional (Clinical Trial)Estimated Enrollment :224 participantsAllocation:RandomizedIntervention Model:Parallel AssignmentMasking:Double (Participant, Outcomes Assessor)Masking Description:Participants undergoing intervention will be unaware of the intervetion Outcomes assessor will be not involted in the other study of the study and will be not aware of the interventionPrimary Purpose:TreatmentOfficial Title:Manually Controlled Infusion vs Target Controlled Infusion: an Hemodynamic Alterations in StrokeThrombectomy Evaluation (HASTE); a Multi-center Randomized Controlled TrialEstimated Study Start Date :October 15, 2022Estimated Primary Completion Date :September 2024Estimated Study Completion Date :December 2024
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Acne
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Age: 100 years or below
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Gender: Male
Ages Eligible for Study: 18 Years and older (Adult, Older Adult)Sexes Eligible for Study: AllAccepts Healthy Volunteers: No
Criteria
Inclusion Criteria:
- Age ≥ 18 years;
- Anterior Cerebral Circulation Stroke
- Patient eligible for mechanical trombectomy
- mRS ≥ 2;
- Fasting patients (>6 h solid, >2 hours liquids)
- Glashow Coma Scale more than seven.
Exclusion criteria
- Patient in general anesthesia at hospital arrival
- Associated hemorrhagic stroke
This study investigates different methods of giving anesthesia to patients with cerebral ischemic stroke. Cerebral ischemic stroke occurs when blood flow to a part of the brain is blocked, leading to potential brain damage. The study compares two methods: manual general anesthesia induction and a method using a target controlled infusion system. The goal is to see which method provides better stability in blood pressure and other hemodynamic factors during surgery.
Participants will receive general anesthesia induction either manually or with a target controlled infusion system. The study will monitor the patients' outcomes to determine if one method leads to better results than the other. This includes observing the patients' recovery and any changes in their condition after the procedure.
- Who can participate: Adults aged 18 and older who have had an anterior cerebral circulation stroke and are eligible for mechanical thrombectomy can participate. Participants must have a Glashow Coma Scale score greater than seven and must have been fasting for more than six hours for solids and more than two hours for liquids. Healthy volunteers are not accepted.
- Study details: Participants will be randomly assigned to receive either manual general anesthesia induction or induction using a target controlled infusion system. The study will compare the outcomes of these two methods. A placebo is not used in this study.
- Study Timelines: The study will last until December 2024.
Updated on
20 Mar 2026.
Study ID: TX112454
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