A Pilot Study to assess Theragnostically Planned Liver Radiation with Functional DVH Analysis to Optimize Individualized Radiation Therapy

Investigating Radiation Treatment Plans for Liver Cancer

Recruiting
18 years - 100 years
All
Phase N/A
1 Location

Brief description of study.

The purpose of this study is to compare radiation treatment plans that are designed for patients with liver cancer.

Detailed description of study

One treatment plan will be created using routine procedures and scans normally performed for radiation treatment planning. The other treatment plan will be created using routine procedures with the addition of two imaging scans; a HIDA (Hepatobiliary Iminodiacetic Acid) scan and an MRI (Magnetic Resonance Imaging) scan. This study will evaluate if adding these imaging scans to treatment planning can reduce the amount of radiation to healthy liver tissue during treatment.


Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: liver cancer,Hepatocellular Carcinoma,Cholangiocarcinoma,hepatic cancer,hepatic,liver,radiation therapy,radiation,cancer,oncology
  • Age: 18 years - 100 years
  • Gender: All

Inclusion Criteria
Primary liver malignancy including hepatocellular carcinoma (HCC) or cholangiocarcinoma
Subjects must have a Child-Turcotte-Pugh (CTP) score less than or equal to 7
Exclusion Criteria
Subject who are pregnant or planning to become pregnant during the study
No more than 3 lesions can be treated. Total diameter of all lesions must be less than or equal to 6 cm
Prior radiation treatment to the upper abdomen
Active infection, active upper GI ulceration or hemorrhage, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia

Updated on 19 Feb 2024. Study ID: 1701880309 (IUSCC-0604)

The purpose of this study is to compare different radiation treatment plans for patients with liver cancer, such as hepatocellular carcinoma or cholangiocarcinoma. This study investigates whether adding specific imaging scans can help reduce radiation exposure to healthy liver tissue. A routine treatment plan will be compared with a plan that includes additional imaging using a HIDA scan and an MRI scan.

Participants will undergo two types of treatment planning. One will use the standard procedures, while the other will include extra imaging scans. The HIDA scan helps visualize liver function, and the MRI provides detailed images of liver structures. By comparing these plans, the study aims to determine if the additional scans can spare healthy liver tissue from radiation.

  • Who can participate: Adults with primary liver cancer, such as hepatocellular carcinoma or cholangiocarcinoma, and a Child-Turcotte-Pugh score of 7 or less may be eligible. Participants should not be pregnant or planning to become pregnant, and must have no more than 3 lesions with a total diameter of 6 cm or less. Previous radiation treatment to the upper abdomen and certain medical conditions may exclude participation.
  • Study details: Participants will undergo two radiation treatment planning sessions. One will use standard imaging techniques, while the other will include a HIDA scan and an MRI scan. The study will compare these plans to see if the additional scans reduce radiation to healthy liver tissue.

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