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Dietary Nitrate and Muscle Power with Aging
Investigation of Investigational Beetroot Juice Effects on Aging
Recruiting
65 years - 79 years
All
Phase
N/A
1 Location
Brief description of study.
The purpose of this study is to see if drinking beetroot juice (BRJ) is beneficial for aging subjects.
Detailed description of study
After you complete a screening visit, if you are determined to be eligible, your participation in the study would involve 6 separate outpatient visits at the Indiana Clinical Research Center at IU-Health University Hospital at 550 University Boulevard in Indianapolis, each 1 week apart. For each visit you will fast for 12 hours. On the first day you will drink beet juice and have your muscle function tested. Samples of your blood and muscle will also be obtained during this visit. Your muscle sample will be obtained by numbing the thigh muscle and making a small incision, and then inserting a needle into the muscle to obtain a small piece of muscle tissue. This procedure is typically painless with only a small amount of pressure being felt. This visit will take approximately 5 hours. After this experiment is over, you would be given a 1 week supply of the beet juice to take with you and drink daily, and you will return 1 week later to provide a blood sample (12 hour fast required) . This visit will take approximately 1 hour. At this point, you will be given another 1 week supply of beet juice, then return to repeat the same experiment as before where you perform the exercise test and provide blood (12 hour fast required) and muscle samples (about 5 hours). After a 2 week “washout” period without drinking beet juice, the above described sequence of tests will then be repeated. During the study you will also wear an activity monitor which tracks how much physical activity you are doing. In total, your participation in the study will last about 2 months.
Participants will be compensated up to $1000 for their participation.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy
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Age: 65 years - 79 years
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Gender: All
Inclusion:
- Men and women age 65-79
- In good health, as determined by a review of your medical history, physical examination, EKG, and routine blood and urine tests
Exclusion:
- Men and women <65 or >79 years of age
- Unable to provide informed consent
- Currently pregnant or lactating
- Current smokers
- Significant orthopedic limitations or other contraindications to strenuous exercise
- Those taking phosphodiesterase inhibitors (e.g., Viagra, Levitra, or Cialis)
- Those taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy
- Those taking anti-coagulants (e.g., Coumadin) or on anti-platelet therapy
- History of major metabolic disease (e.g., type I and type II diabetes, thyroid disorders), neuromuscular disease (e.g., cervical spondylotic radiculomyelopathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies), cardiovascular disease (e.g., > stage II hypertension, heart failure, myocardial infarction/ischemia, significant myocardial or pericardial diseases (e.g. amyloidosis, constriction), moderate or severe valvular disease, renal disease, liver disease, or anemia
Updated on
19 Feb 2024.
Study ID: 1712579448
This study investigates the effects of drinking beetroot juice on muscle function in older adults. The purpose of the study is to understand whether beetroot juice can benefit individuals aged 65 to 79. Participants will be required to drink beetroot juice and their muscle function will be tested. Muscle function refers to how well muscles can perform tasks and is measured through physical tests.
Participants will undergo a series of tests including blood and muscle sampling. A muscle sample will be taken by numbing the thigh and making a small cut to insert a needle for tissue collection. This procedure is designed to be painless. Participants will also wear an activity monitor to track their physical activity levels during the study.
- Who can participate: Men and women aged 65 to 79 who are in good health can participate. Key eligibility factors include not being pregnant, not smoking, and not having significant medical conditions like cardiovascular or metabolic diseases.
- Study details: Participants will drink beetroot juice and have their muscle function tested. They will also provide blood and muscle samples.
- Study Timelines and Visits: The study will last about 2 months. The study requires 6 visits.
Pre-Screener
