Chronic Headache due to Mild Traumatic Brain Injury in Adults: Alterations of Brain Function Central Sensitization and Inflammatory Processes

Investigating Headaches After Mild Brain Injury

Recruiting
18 years - 65 years
All
Phase N/A
1 Location

Brief description of study.

The purpose of this study is to teach us more about why some people often experience headaches after having a mild traumatic brain injury. We need individuals who have NOT experienced a traumatic brain injury.

Detailed description of study

The purpose of this study is to teach us more about why some people often experience headaches after having a mild traumatic brain injury. We want to determine whether certain factors place individuals more at risk for experiencing headaches after a mild traumatic brain injury including pain sensitivity, how the body adapts to pain, levels of inflammation in our blood, and changes in brain structure and function.
Participants will be compensated for their participation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: healthy,headache
  • Age: 18 years - 65 years
  • Gender: All

Inclusion Criteria
In good health
Have not had a traumatic brain injury
Do not experience chronic headaches
Exclusion Criteria
Chronic cardiovascular disease, metabolic disease, or renal disease
Neurological disease (e.g., Parkinson's Disease, multiple sclerosis, epilepsy)
Serious psychiatric conditions (schizophrenia, bipolar disorder) or hospitalization within the preceding year for psychiatric illness
Pre-existing chronic headache defined as having headache > 15 days/month over the past 3 months
Fractures of any kind
Chronic opioid use
Current use of narcotics
Uncontrolled hypertension (or receiving treatment for hypertension with BP of greater than 150/99)
Current involvement in litigation
No metallic foreign bodies in the brain or eye or cardiac pacemakers
Previous traumatic brain injury

Updated on 19 Feb 2024. Study ID: 1804170492

This study investigates why some people often experience headaches after having a mild traumatic brain injury. A mild traumatic brain injury is a condition where the brain is affected by a sudden impact, but symptoms are not as severe as in more serious brain injuries. Researchers aim to understand whether factors like pain sensitivity, how the body adapts to pain, levels of inflammation in the blood, and changes in brain structure and function contribute to the risk of headaches.

Participants in this study will undergo various procedures to assess these factors. This may include blood tests to measure inflammation, tests to evaluate pain sensitivity, and possibly imaging to observe changes in brain structure and function. The study aims to gather data to better understand these associations.

  • Who can participate: Adults in good health without a history of traumatic brain injury or chronic headaches are eligible. Those with chronic diseases, neurological, or psychiatric conditions are excluded.
  • Study details: Participants will have blood tests, pain sensitivity assessments, and imaging studies to explore the link between mild traumatic brain injury and headaches.

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