This study investigates how well low-dose versus high-dose investigational medication works in younger patients with certain brain tumors. These tumors include juvenile pilocytic astrocytomas and optic nerve pathway gliomas, which may have returned, not responded to treatment, or are worsening. The purpose of this study is to determine how effective the treatment is in managing these conditions.
Participants will be assigned to one of two study arms: Regimen A, which involves a low-dose treatment, or Regimen B, which involves a high-dose treatment. The study will compare the effectiveness of these two dosing regimens.
- Who can participate: Patients aged 18 years or younger with juvenile pilocytic astrocytomas or optic nerve pathway gliomas that are recurrent, refractory, or progressive may be eligible to participate.
- Study details: Participants will receive either a low-dose or high-dose of the investigational medication, depending on the study arm they are assigned to.
