This study is currently not recruiting participants.

A Rapid Point of Care diagnosis and Screening for Cryptococcal Meningitis in HIV Infected African Patients: A Prospective Multi-Phase Study

Investigation of CRAG (Cryptococcal Antigen) Detection Methods for Cryptococcal Antigen

Not Recruiting
100 years or below
All
Phase N/A

Brief description of study.

The primary objective is to determine the sensitivity and specificity of the CSF, serum and urine CRAG Lateral Flow Assay (LFA) for the detection of Cryptococcal Antigen (CRAG) compared with the standard CSF CRAG Latex Agglutination (LA) method.

Detailed description of study

The primary objective is to determine the sensitivity and specificity of the CSF, serum and urine CRAG Lateral Flow Assay (LFA) for the detection of Cryptococcal Antigen (CRAG) compared with the standard CSF CRAG Latex Agglutination (LA) method.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Meningitis
  • Age: 100 years or below
  • Gender: All

This study investigates the effectiveness of different methods to detect Cryptococcal Antigen (CRAG), a substance that indicates a fungal infection called cryptococcosis. The study compares the new CRAG Lateral Flow Assay (LFA) with the standard method known as CRAG Latex Agglutination (LA).

Participants in this study will undergo tests using the CRAG LFA on samples of their cerebrospinal fluid (CSF), serum, and urine. These tests are designed to measure how well the CRAG LFA detects the presence of the Cryptococcal Antigen compared to the traditional LA method.

  • Who can participate: No specific eligibility criteria provided.
  • Study details: Participants will provide samples of cerebrospinal fluid, serum, and urine for testing. The study will compare the results from the investigational CRAG LFA with the standard LA method. An inactive substance that looks like the investigational medicine/vaccine but does not contain any medicine may be used as a placebo.
Updated on 19 Feb 2024. Study ID: 1303010918

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