This study is currently not recruiting participants.

Effects of Stannous Fluoride on Porphyromonas gingivalis Stimulated and Unstimulated Human Gingival Fibroblasts: Toxicity Matrix Metalloproteinase Expression and COLIA Expression

Study on Fluoride Effects on Gum Cells

Not Recruiting
100 years or below
All
Phase N/A

Brief description of study.

We will test the effects of stannous fluoride and sodium fluoride on human gingival fibroblasts in terms of expression of matrix metalloprotienases and type I collagen in an in vitro environment.

Detailed description of study

We will test the effects of stannous fluoride and sodium fluoride on human gingival fibroblasts in terms of expression of matrix metalloprotienases and type I collagen in an in vitro environment.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Human Gingival Fibroblasts
  • Age: 100 years or below
  • Gender: All

This study investigates the effects of different types of fluoride on gum cells. Specifically, it looks at how stannous fluoride and sodium fluoride affect the production of certain proteins in the cells that make up the gums. These proteins include matrix metalloproteinases, which help break down proteins, and type I collagen, which provides structure and strength to tissues.

Participants in the study will have their gum cells exposed to these fluoride types in a controlled laboratory setting. The study will measure changes in the levels of these proteins to understand how the different fluoride types impact gum health.

  • Who can participate: This is an in vitro study and does not involve human participants.
  • Study details: The study involves testing human gingival fibroblasts with fluoride in a lab to compare effects on protein levels.
Updated on 19 Feb 2024. Study ID: 1401436481

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