Dominantly Inherited Alzheimer Network (DIAN)
Research Study on Changes in Inherited Alzheimer Disease
Brief description of study.
The overall purpose of this research is to understand the changes that occur in dominantly inherited Alzheimer disease.
Detailed description of study
The overall purpose of this research is to understand the changes that occur in dominantly inherited Alzheimer disease.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Alzheimer,Alzheimer Disease,Alzheimers,Alzheimers Disease,Alzheimer's,Alzheimer's Disease,AD
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Age: 18 years - 100 years
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Gender: All
Inclusion Criteria
Participant is cognitively normal or if demented does not require nursing home-level care.
Participant has identified two persons (minimum of one) who are not their full-blooded siblings who can serve as collateral sources for the study.
Participant is fluent in English at the 6th grade level or above
Exclusion Criteria
Pregnant women should not complete any in-person visit measures
Treatment with blood thinners, e.g. Warfarin
Coagulation abnormalities
Lumbar spinal surgery within the last 6 months prior to screening, or any lumbar spinal surgery that interferes with anatomy of the inter-vertebral spaces.
History of chronic or repeat CSF leakage following previous LP(s)
Active infectious process
Current or recent participation in research studies involving radioactive agents
Pacemakers
Electronically, magnetically, and mechanically activated implants
Metallic splinters in the eye
Ferromagnetic haemostatic clips in the central nervous system
This study investigates the changes that occur in dominantly inherited Alzheimer disease. Dominantly inherited Alzheimer disease is a form of Alzheimer's that is passed down through families, meaning it is inherited from a parent who also had the condition. The study aims to understand how this disease develops and progresses over time.
Participants in the study will undergo various procedures to gather information about their condition. These procedures may include cognitive tests and medical imaging. Participants will also be required to provide information from individuals who know them well, which helps in understanding the disease's impact.
- Who can participate: Individuals who are cognitively normal or have dementia but do not require nursing home-level care are eligible. Participants must be fluent in English at the 6th grade level or above and provide collateral sources.
- Study details: Participants will take part in cognitive tests and medical imaging. They must also provide information from individuals who know them well.
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