Post-TBI Irritability and Aggression: Building Evidence-Based Approaches to Management

Investigating Treatment for Irritability and Aggression After Brain Injury

Post-TBI Irritability and Aggression: Building Evidence-Based Approaches to Management
Recruiting
18 years - 70 years
All
Phase N/A
1 Location

Brief description of study.

The purpose of the study is to see if buspirone is effective in treating irritability and aggression in people who have had a traumatic brain injury.

Detailed description of study

The purpose of the study is to see if buspirone is effective in treating irritability and aggression in people who have had a traumatic brain injury.
Participants will be paid for their participation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Traumatic Brain Injury,TBI,Brain Injury,Neurology,Irritability,Aggression
  • Age: 18 years - 70 years
  • Gender: All

Inclusion Criteria
Closed head injury at least 6 months prior to enrollment
Irritability/aggression
Observer with whom subject interacts sufficiently to observe occurences of irritability
Exclusion Criteria
Ingestion of buspirone during the month prior to enrollment
History of schizophrenia or psychosis  
Uncontrolled seizure disorder

Updated on 19 Feb 2024. Study ID: 1210009885

This study investigates the use of an investigational medication to treat irritability and aggression in individuals who have experienced a traumatic brain injury. Traumatic brain injury, or TBI, occurs when a sudden trauma causes damage to the brain, which can lead to changes in behavior, including increased irritability and aggression.

Participants in this study will receive either the investigational medication or a placebo. A placebo is an inactive substance that looks like the investigational medicine but does not contain any medicine. Participants will be monitored for changes in their behavior to assess the effectiveness of the treatment.

  • Who can participate: Adults who suffered a closed head injury at least 6 months ago and experience irritability or aggression may participate. They must have an observer who can report on their behavior. Individuals who have taken the investigational medication recently, or have certain mental health conditions, are not eligible.
  • Study details: Participants will receive either the investigational medication or a placebo.

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