Role of keratinocyte-derived cytokines in epidermal injury and atopic dermatitis
Investigation of Skin Proteins in Atopic Dermatitis and Psoriasis
Brief description of study.
The purpose of this study is to examine a protein from the skin of people with atopic dermatitis and compare with those who do not have this disease.
Detailed description of study
The purpose of this study is to characterize the functions of IL-33 in and on cells in human skin isolated from patients with atopic dermatitis, control patients with psoriasis and healthy subjects.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: healthy
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Age: 21 years - 100 years
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Gender: All
Inclusion Criteria
For subjects with atopic dermatitis, only patients with active atopic dermatitis will be enrolled
For subjects with psoriasis, only patients with active plaque psoriasis will be enrolled
Exclusion Criteria
Patients without active atopic dermatitis
Patients without active plaque psoriasis
No current or use within the past 6 months of any systemic immunosuppressants including systemic steroids, methotrexate, cyclosporine, azathioprine, mycophenolate mofetil, acitretin, isotretinoin, TNFalpha inhibitors and ustikenumab
No prior use of UVB- or UVA-based phototherapies or tanning beds within the past 3 months
No current or use within the past 1 week of topical steroids, topical calcineurin inhibitors or other toopical medications (other than bland emollients) on the skin sites that will be used for the proposed studies
No history of abnormal scarring
No history of allergy to lidocaine or other amide local anesthetics
No history of systemic immunosuppression or abnormal serious skin infections necessitating hospitalization
No history of bleeding disorders or use of anticoagulants
The purpose of this study is to investigate proteins found in the skin of people with atopic dermatitis and compare them to those without the condition. This study also aims to understand the functions of a protein called IL-33 in skin cells from patients with atopic dermatitis, those with psoriasis, and healthy individuals. IL-33 is a protein that plays a role in the body's immune response.
During the study, participants will undergo procedures to collect skin samples. These samples will be analyzed to study the proteins and the role of IL-33. Participants will be compensated for their involvement in the study.
- Who can participate: Individuals with active atopic dermatitis or plaque psoriasis who have not recently used systemic immunosuppressants and do not have a history of abnormal scarring or allergies to certain anesthetics are eligible.
- Study details: Participants will provide skin samples for analysis. The study will compare these samples to understand protein functions. A placebo is not involved in this study.
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