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Found 410 ctsi-central-admin trials

A listing of ctsi-central-admin medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A PHASE II TRIAL OF EPIGENETIC PRIMING IN PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA

22 or below
All genders
The purpose of this study is to determine if epigenetic priming with DNA methyltransferase inhibitors (DMTi) prior to chemotherapy blocks is safe and effective in treating children with acute myeloid leukemia (AML).
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A Multicenter Phase II Study of Vaccines to Prevent Recurrence in Patients with HER-2 Positive Breast Cancer

18 - 100
All genders
The main purpose of this study is to evaluate the safety of each investigational study vaccine and to evaluate the effect on the time to disease recurrence (assessed by disease free survival).
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A Randomized Phase II/III Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

60 - 100
All genders
The purpose of this study is to see if we lower the chance of AML returning or getting worse by adding a new drug to the usual combination of drugs.
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BMT CTN 1703/1801: A Randomized, Multi-Center, Phase III Trial of Tacrolimus/ Methotrexate versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (PROGRESS III)/Companion Study: Microbiome and Immune Reconstitution in Cellular Therapies and Hematopoietic Stem Cell Transplantation (Mi-Immune)

18 - 100
All genders
The primary objective of the trial is to compare 1 year GVHD-free, relapse-free survival (GRFS) between the two GVHD prophylaxis regimens.
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Intelligibility of speakers with and without aphasia

18 - 35
Accepts healthy volunteer
All genders
People with aphasia can speak very fluently but make little sense or can speak non-fluently making it difficult to understand their intended message. This research will investigate how well listeners are able to understand the speech of people with aphasia compared speakers without aphasia
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The Farm as Lab: IT Innovation in Computational Agriculture

18 - 100
All genders
Since 2016, we have conducted preliminary studies of over a dozen self-described experimental farms in the United States and Asia. Despite their different locations, purposes, and scales, they all shared a single feature: all of the farms we engaged with were founded and operated by former professionals from non-agricultural disciplines, …
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Effects of Precuneus Repetitive Transcranial Magnetic Stimulation (rTMS) on Self-Referential Processing and Default Mode Network Functional Connectivity in Early Phase Psychosis

18 - 45
All genders
Interventional
The purpose of this study is to determine if the study treatment, repetitive transcranial magneticstimulation (rTMS), helps improve symptoms of your illness and adjusts communication betweenrelated areas of the brain. rTMS is a non-invasive technique that applies a magnetic field over the scalpto cause activation within the brain.
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Smartphone-based Hearing Conservation for Farm and Rural Youth

13 - 18
All genders
The purpose of this research study is to evaluate if hearing conservation education via smartphone apps can increase hearing protection use among adolescent farmworkers in rural Indiana. This study will present educational information about hearing health and hearing conservation utilizing either two smartphone apps and/or printed leaflets published by the …
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Validation Study of a Sensor for Monitoring Sleep.

18 - 100
Accepts healthy volunteer
All genders
The study aims to research people with Alzheimer’s Disease and other forms of cognitive impairment, and their caregivers and family members, that suffer from various forms of sleep disturbance. No-contact sensor prototype has been developed. This study will compare the results of the no-contact sleep sensor prototype, hereafter Sleep Monitor, …
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Phase I/II study augmenting TAK-659 action in relapsed/refractory AML by addition of the proteasome inhibitor Ixazomib Big Ten Cancer Research Consortium BTCRC-HEM17-092

18 - 100
All genders
Phase 1/2
The purpose of this study is to test the safety and efficacy of combining two drugs, ixazomib and TAK-659. It will also evaluate the number of patients whose tumor responded after receiving ixazomib and TAK-659.
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