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Found 204 Neoplasms trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigating the Safety and Dosage of an Investigational Antibody in Treating Recurrent Solid Tumors in Children

1 - 30
All genders
This study investigates the effects of an investigational antibody in treating children with solid tumors that have come back or do not respond to treatment. The purpose of this study is to find the best dose and understand the side effects of the investigational antibody. The study focuses on children …
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Investigational Medication Safety in Children with Brain Tumors

2 - 21
All genders
This study investigates the safety and effects of an investigational medication in children with high-grade gliomas, a type of brain tumor that is difficult to treat. High-grade gliomas are classified as WHO grade III or IV tumors, which are aggressive and fast-growing. The study focuses on pediatric patients who have …
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Investigation of Treatments for Metastatic Castration-Resistant Prostate Cancer with DNA Repair Defects

18 - 100
Male
This study investigates treatments for men with metastatic castration-resistant prostate cancer (mCRPC) who have DNA repair defects. The purpose is to assess the effectiveness of two drugs that are approved by the US FDA, both individually and in combination. Metastatic castration-resistant prostate cancer is a type of prostate cancer that …
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Study of Chemotherapy and Surgery for Liver Cancer in Children and Young Adults

30 or below
All genders
This study investigates how well chemotherapy works in treating children and young adults with liver cancer, specifically hepatoblastoma and hepatocellular carcinoma, after surgery. Hepatoblastoma is a rare liver cancer that occurs in children, while hepatocellular carcinoma is a more common type of liver cancer that can affect young adults. The …
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Investigating Pelvic Floor Muscle Training for Quality of Life After Prostate Gland Surgery

18 - 100
Male
This study investigates whether training the pelvic floor muscles with a physical therapist before and after prostate surgery can improve the quality of life related to health after the surgery. The pelvic floor muscles support the bladder and bowel and help with urinary control. The study focuses on men undergoing …
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Study of Investigational Medication for Advanced Solid Tumors

18 - 100
All genders
This study investigates an investigational medication for adults with advanced solid tumors that do not respond to standard treatments or for whom no effective treatment exists. Solid tumors are masses of tissue that arise from abnormal cell growth. The study includes two parts: an initial phase to find the highest …
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Study of Investigational Medication for Patients with Progressive Disease on Anti-PD-1/PD-L1 Therapy

18 - 100
All genders
This study investigates the safety and effects of an investigational medication in patients with cancer who have not responded to certain cancer treatments. These treatments, known as anti-PD-1 or anti-PD-L1 therapies, are designed to help the immune system fight cancer. The study will focus on patients who either saw their …
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Study on Dose-Intensive Tandem Consolidation for CNS Tumors

10 or below
All genders
This study investigates the effects of dose-intensive tandem consolidation compared to a single cycle consolidation on event-free survival and overall survival in patients with certain central nervous system (CNS) tumors. CNS tumors can occur in the brain or spinal cord, and this study focuses on conditions like medulloblastoma and other …
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Investigating the Safety and Dosage of an Investigational Medication with Irinotecan for Solid Tumors in Children

1 - 21
All genders
This study investigates the use of an investigational medication in combination with irinotecan for treating children with solid tumors that have returned or not responded to standard treatments. Solid tumors are abnormal masses of tissue that usually do not contain cysts or liquid areas. The purpose of this study is …
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Investigating Lower Dose Stereotactic Radiosurgery for Brain Metastases

18 - 100
All genders
Interventional
This study investigates the effects of using a lower dose of stereotactic radiosurgery, such as Gamma Knife or Linear Accelerator, for patients with brain metastases who are also receiving immunotherapy. Brain metastases occur when cancer cells spread from their original site to the brain. The study aims to understand if …
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